Most of the drug treatments which are prescribed are for relief of symptoms. They do not offer a cure for the condition. There are various non-steroidal anti-inflammatory drugs, which are used for providing prompt relief of associated pain as well as inflammation. These are considered relatively safe. Examples of NSAIDs are aspirin, indomethacin, ibuprofen, as well as naproxen and piroxicam.

COX-2 inhibitors refer to a new class of anti-inflammatory drugs. These selectively block the COX-2 enzyme. This helps in preventing the production of chemical messengers or prostaglandins which are behind the pain as well as the swelling of arthritis.

Drugs like hydroxychloroquine, gold, as well as penicillamine, azathioprine, and sulfasalazine besides methotrexate are used for controlling the symptoms. These also help to delay the disease progression in patients who have rheumatoid arthritis. These are second-line drugs which are slower acting, and are usually taken together with NSAIDs.

Steroids are also used for joint pain relief. These may be taken orally in low doses, or even as injections in the affected joint. These are prescribed for providing rapid relief of pain, swelling as well as inflammation around the affected joints.

Glucosamine as well as chondroitin sulphate are used in patients who are suffering from osteoarthritis. Both of these are dietary supplements. They ease symptoms in people who have moderate to severe joint pain. These substances can also help to restore cartilage. Unlike the commonly prescribed NSAIDs, these supplements are not associated with any kind of side effects. Any kind of drug treatment for joint pain relief should be monitored by a physician. This is because it needs to be tailored to individual needs.

Dietary supplements are also being used to manage specific painful joint conditions. Glucosamine as well as chondroitin sulfate are used in patients who have osteoarthritis. These supplements are used to replenish the worn-down connective tissue that is cushioning the bones. Others dietary supplements include niacinamide, S-adenosylmethionine (SAMe), as well as ginger and turmeric.

Physical therapy is usually prescribed as a treatment for people who have joint pain. This may be daily walking; stretching exercises, or even include muscle-strengthening exercises which will be under supervision. Traction, massage, as well as manipulation of joints lead to improved joint mobility besides flexibility. Surgical procedures are required either to determine the cause of joint pain or to provide joint pain relief in case of severely damaged joints.